RecG

• Description: ATP-dependent DNA helicase, branch migration translocase, required for DNA repair and chromosomal segregation
  
  

Gene name	recG
Synonyms	ylpB
Essential	no
Product	ATP-dependent DNA helicase, branch migration translocase
Function	DNA repair and chromosomal segregation
Gene expression levels in SubtiExpress: recG
Interactions involving this protein in SubtInteract: RecG
Metabolic function and regulation of this protein in SubtiPathways: recG
MW, pI	77 kDa, 7.093
Gene length, protein length	2046 bp, 682 aa
Immediate neighbours	sdaAA, fapR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination

The gene

Basic information

• Locus tag: BSU15870

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: helicase C-terminal domain (according to Swiss-Prot)

• Paralogous protein(s): Mfd

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SsbA-RecG PubMed

• Localization:

Database entries

• Structure: 1GM5 (from Thermotoga maritima, 43% identity, 62% similarity)

• UniProt: O34942

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: recG PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A897 (no resistance), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)

Humberto Sanchez, Begoña Carrasco, M Castillo Cozar, Juan C Alonso
Bacillus subtilis RecG branch migration translocase is required for DNA repair and chromosomal segregation.
Mol Microbiol: 2007, 65(4);920-35
[PubMed:17640277] [WorldCat.org] [DOI] (P p)

Qin Wen, Akeel A Mahdi, Geoffrey S Briggs, Gary J Sharples, Robert G Lloyd
Conservation of RecG activity from pathogens to hyperthermophiles.
DNA Repair (Amst): 2005, 4(1);23-31
[PubMed:15533834] [WorldCat.org] [DOI] (P p)

Additional publications: PubMed