AdeR

• Description: transcription activator (PucR family) for ald gene expression
  
  

Gene name	adeR
Synonyms	yukF
Essential	no
Product	transcription activator (PucR family)
Function	control of ald expression
MW, pI	50 kDa, 8.147
Gene length, protein length	1302 bp, 434 aa
Immediate neighbours	yukE, ald
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, utilization of amino acids

The AdeR regulon

• ald

The gene

Basic information

• Locus tag: BSU31920

Phenotypes of a mutant

• sporulation defect due to lack of ald expression PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription activation of ald gene expression in the presence of alanine PubMed

• Protein family: PucR family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on Ser-395 PubMed

• Cofactor(s):

• Effectors of protein activity: L-alanine PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P71073

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: adeR PubMed

• Expression browser: adeR PubMed

• Sigma factor:

• Regulation:
  • constitutively expressed PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ta-Hui Lin, Guei-Tsung Wei, Chien-Chen Su, Gwo-Chyuan Shaw
AdeR, a PucR-type transcription factor, activates expression of L-alanine dehydrogenase and is required for sporulation of Bacillus subtilis.
J Bacteriol: 2012, 194(18);4995-5001
[PubMed:22797752] [WorldCat.org] [DOI] (I p)

Boumediene Soufi, Chanchal Kumar, Florian Gnad, Matthias Mann, Ivan Mijakovic, Boris Macek
Stable isotope labeling by amino acids in cell culture (SILAC) applied to quantitative proteomics of Bacillus subtilis.
J Proteome Res: 2010, 9(7);3638-46
[PubMed:20509597] [WorldCat.org] [DOI] (I p)

K J Siranosian, K Ireton, A D Grossman
Alanine dehydrogenase (ald) is required for normal sporulation in Bacillus subtilis.
J Bacteriol: 1993, 175(21);6789-96
[PubMed:8226620] [WorldCat.org] [DOI] (P p)