YvrI

• Description: RNA polymerase sigma factor YvrI
  
  

Gene name	yvrI
Synonyms	sigO
Essential	no
Product	co-sigma factor with YvrHa
Function	RNA polymerase sigma factor
Gene expression levels in SubtiExpress: yvrI
Interactions involving this protein in SubtInteract: YvrI
MW, pI	20.76 kDa, 9.36
Gene length, protein length	531 bp, 176 aa
Immediate neighbours	yvrHa, yvrJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription, sigma factors and their control, acid stress proteins (controlled by YvrI-YvrHa)

This gene is a member of the following regulons

YvrHb regulon, YvrI-YvrHa regulon

The YvrI-YvrHa regulon

• oxdC-yvrL
• yvrI-yvrHa
• yvrJ

The gene

Basic information

• Locus tag: BSU33230

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: contains a DNA-binding helix-turn-helix motif (HTH) and the region 4.2 of Sigma factors PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • YvrI-RpoB PubMed
  • YvrI-YvrHa PubMed

• Localization:

Database entries

• Structure:

• UniProt: O34843

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yvrI-yvrHa PubMed

• Expression browser: yvrI PubMed

• Sigma factor: YvrI-YvrHa PubMed

• Regulation: induced by acidic growth conditions PubMed

• Regulatory mechanism: activated by YvrHb PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

Shawn R MacLellan, Veronica Guariglia-Oropeza, Ahmed Gaballa, John D Helmann
A two-subunit bacterial sigma-factor activates transcription in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21323-8
[PubMed:19940246] [WorldCat.org] [DOI] (I p)

Shawn R MacLellan, John D Helmann, Haike Antelmann
The YvrI alternative sigma factor is essential for acid stress induction of oxalate decarboxylase in Bacillus subtilis.
J Bacteriol: 2009, 191(3);931-9
[PubMed:19047353] [WorldCat.org] [DOI] (I p)

Shawn R MacLellan, Tina Wecke, John D Helmann
A previously unidentified sigma factor and two accessory proteins regulate oxalate decarboxylase expression in Bacillus subtilis.
Mol Microbiol: 2008, 69(4);954-67
[PubMed:18573182] [WorldCat.org] [DOI] (I p)

Masakuni Serizawa, Keisuke Kodama, Hiroki Yamamoto, Kazuo Kobayashi, Naotake Ogasawara, Junichi Sekiguchi
Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses.
Biosci Biotechnol Biochem: 2005, 69(11);2155-69
[PubMed:16306698] [WorldCat.org] [DOI] (P p)