SpoIIM

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  • Description: required for dissolution of the septal cell wall

Gene name spoIIM
Synonyms
Essential no
Product sporulation protein
Function dissolution of the septal cell wall
Gene expression levels in SubtiExpress: spoIIM
Interactions involving this protein in SubtInteract: SpoIIM
MW, pI 24 kDa, 9.84
Gene length, protein length 642 bp, 214 aa
Immediate neighbours fur, yqkK
Sequences Protein DNA DNA_with_flanks
Genetic context
SpoIIM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoIIM expression.png















Categories containing this gene/protein

cell wall/ other, sporulation proteins

This gene is a member of the following regulons

SigE regulon

The gene

Basic information

  • Locus tag: BSU23530

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed early during sporulation in the mother cell (SigE) PubMed
    • subject to negative control by YlbO PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jennifer Fredlund, Dan Broder, Tinya Fleming, Clémence Claussin, Kit Pogliano
The SpoIIQ landmark protein has different requirements for septal localization and immobilization.
Mol Microbiol: 2013, 89(6);1053-68
[PubMed:23859254] [WorldCat.org] [DOI] (I p)

Arnaud Chastanet, Richard Losick
Engulfment during sporulation in Bacillus subtilis is governed by a multi-protein complex containing tandemly acting autolysins.
Mol Microbiol: 2007, 64(1);139-52
[PubMed:17376078] [WorldCat.org] [DOI] (P p)

Thierry Doan, Kathleen A Marquis, David Z Rudner
Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum.
Mol Microbiol: 2005, 55(6);1767-81
[PubMed:15752199] [WorldCat.org] [DOI] (P p)

Patrick Eichenberger, Masaya Fujita, Shane T Jensen, Erin M Conlon, David Z Rudner, Stephanie T Wang, Caitlin Ferguson, Koki Haga, Tsutomu Sato, Jun S Liu, Richard Losick
The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis.
PLoS Biol: 2004, 2(10);e328
[PubMed:15383836] [WorldCat.org] [DOI] (I p)

P Eichenberger, P Fawcett, R Losick
A three-protein inhibitor of polar septation during sporulation in Bacillus subtilis.
Mol Microbiol: 2001, 42(5);1147-62
[PubMed:11886548] [WorldCat.org] [DOI] (P p)

K Smith, P Youngman
Evidence that the spoIIM gene of Bacillus subtilis is transcribed by RNA polymerase associated with sigma E.
J Bacteriol: 1993, 175(11);3618-27
[PubMed:8501065] [WorldCat.org] [DOI] (P p)