LrpC

• Description: sequence-independent DNA-binding and DNA-bending protein (Lrp family), facilitates the formation of higher order protein-DNA complexes
  
  

Gene name	lrpC
Synonyms	ydaI
Essential	no
Product	DNA-binding and -bending protein
Function	DNA repair/ recombination
Gene expression levels in SubtiExpress: lrpC
MW, pI	16 kDa, 7.743
Gene length, protein length	432 bp, 144 aa
Immediate neighbours	ydzA, topB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination

The gene

Basic information

• Locus tag: BSU04250

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: (Lrp family)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2CFX

• UniProt: P96582

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: lrpC PubMed

• Expression browser: lrpC PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information: 50 ... 300 molecules per cell PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Paul Thaw, Svetlana E Sedelnikova, Tatyana Muranova, Sebastian Wiese, Sylvia Ayora, Juan C Alonso, Arie B Brinkman, Jasper Akerboom, John van der Oost, John B Rafferty
Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.
Nucleic Acids Res: 2006, 34(5);1439-49
[PubMed:16528101] [WorldCat.org] [DOI] (I e)

Gema López-Torrejón, María I Martínez-Jiménez, Silvia Ayora
Role of LrpC from Bacillus subtilis in DNA transactions during DNA repair and recombination.
Nucleic Acids Res: 2006, 34(1);120-9
[PubMed:16407330] [WorldCat.org] [DOI] (I e)

Christophe Beloin, Josette Jeusset, Bernard Revet, Gilles Mirambeau, Francoise Le Hégarat, Eric Le Cam
Contribution of DNA conformation and topology in right-handed DNA wrapping by the Bacillus subtilis LrpC protein.
J Biol Chem: 2003, 278(7);5333-42
[PubMed:12458218] [WorldCat.org] [DOI] (P p)

C Beloin, R Exley, A L Mahé, M Zouine, S Cubasch, F Le Hégarat
Characterization of LrpC DNA-binding properties and regulation of Bacillus subtilis lrpC gene expression.
J Bacteriol: 2000, 182(16);4414-24
[PubMed:10913073] [WorldCat.org] [DOI] (P p)

A Tapias, G López, S Ayora
Bacillus subtilis LrpC is a sequence-independent DNA-binding and DNA-bending protein which bridges DNA.
Nucleic Acids Res: 2000, 28(2);552-9
[PubMed:10606655] [WorldCat.org] [DOI] (I p)

C Beloin, S Ayora, R Exley, L Hirschbein, N Ogasawara, Y Kasahara, J C Alonso, F L Hégarat
Characterization of an lrp-like (lrpC) gene from Bacillus subtilis.
Mol Gen Genet: 1997, 256(1);63-71
[PubMed:9341680] [WorldCat.org] [DOI] (P p)