Cofactors

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Contents

1 NAD(+)
2 Copper
3 Nickel
4 Manganese
5 Heme A
6 Thiamine pyrophosphate
- 6.1 E1 subunits of ketoacid dehydrogenases/ acetoin dehydrogenase
7 Lipoic acid
- 7.1 E2 subunits of ketoacid dehydrogenases/ acetoin dehydrogenase
- 7.2 H protein of the glycine cleavage system
8 pyridoxyl phosphate
9 tetrahydrofalate

NAD(+)

LplD

Copper

CtaC (Cu(A))
CtaD (Cu(B))
QoxB (Cu(B))
Sco

Nickel

UreA-UreB-UreC (urease), the nickel ion binds the active site in UreC

Manganese

LplD

Heme A

CtaD

Thiamine pyrophosphate

E1 subunits of ketoacid dehydrogenases/ acetoin dehydrogenase

PdhA

Lipoic acid

E2 subunits of ketoacid dehydrogenases/ acetoin dehydrogenase

H protein of the glycine cleavage system

GcvH (also required for LipL-catalyzed octanoyl transfer from AcpA to the E2s)

pyridoxyl phosphate

GcvP

tetrahydrofalate

GcvT

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