CotS

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  • Description: outer spore coat protein

Gene name cotS
Synonyms
Essential no
Product spore coat protein
Function resistance of the spore
Gene expression levels in SubtiExpress: cotS
MW, pI 40 kDa, 6.641
Gene length, protein length 1053 bp, 351 aa
Immediate neighbours ytxO, cotSA
Sequences Protein DNA DNA_with_flanks
Genetic context
CotS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CotS expression.png















Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

SigK regulon, GerE regulon

The gene

Basic information

  • Locus tag: BSU30900

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: cotS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed late during sporulation in the mother cell (SigK, GerE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Peter T McKenney, Patrick Eichenberger
Dynamics of spore coat morphogenesis in Bacillus subtilis.
Mol Microbiol: 2012, 83(2);245-60
[PubMed:22171814] [WorldCat.org] [DOI] (I p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Patrick Eichenberger, Masaya Fujita, Shane T Jensen, Erin M Conlon, David Z Rudner, Stephanie T Wang, Caitlin Ferguson, Koki Haga, Tsutomu Sato, Jun S Liu, Richard Losick
The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis.
PLoS Biol: 2004, 2(10);e328
[PubMed:15383836] [WorldCat.org] [DOI] (I p)

Ritsuko Kuwana, Hiromi Ikejiri, Satoko Yamamura, Hiromu Takamatsu, Kazuhito Watabe
Functional relationship between SpoVIF and GerE in gene regulation during sporulation of Bacillus subtilis.
Microbiology (Reading): 2004, 150(Pt 1);163-170
[PubMed:14702409] [WorldCat.org] [DOI] (P p)

S Little, A Driks
Functional analysis of the Bacillus subtilis morphogenetic spore coat protein CotE.
Mol Microbiol: 2001, 42(4);1107-20
[PubMed:11737650] [WorldCat.org] [DOI] (P p)

H Takamatsu, T Kodama, K Watabe
Assembly of the CotSA coat protein into spores requires CotS in Bacillus subtilis.
FEMS Microbiol Lett: 1999, 174(1);201-6
[PubMed:10234840] [WorldCat.org] [DOI] (P p)

H Takamatsu, Y Chikahiro, T Kodama, H Koide, S Kozuka, K Tochikubo, K Watabe
A spore coat protein, CotS, of Bacillus subtilis is synthesized under the regulation of sigmaK and GerE during development and is located in the inner coat layer of spores.
J Bacteriol: 1998, 180(11);2968-74
[PubMed:9603889] [WorldCat.org] [DOI] (P p)

Akiko Abe, Hidekatsu Koide, Takeyuki Kohno, Kazuhito Watabe
A Bacillus subtilis spore coat polypeptide gene, cotS.
Microbiology (Reading): 1995, 141 ( Pt 6);1433-1442
[PubMed:7545510] [WorldCat.org] [DOI] (P p)