DgrA

• Description: c-di-GMP receptor protein, inhibits motility at high c-di-GMP concentrations
  
  

Gene name	dgrA
Synonyms	ypfA, jofA
Essential	no
Product	c-di-GMP receptor protein
Function	control of MotA activity
Gene expression levels in SubtiExpress: DgrA
Interactions involving this protein in SubtInteract: DgrA
MW, pI	24 kDa, 7.878
Gene length, protein length	651 bp, 217 aa
Immediate neighbours	ypfB, ypeB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

motility and chemotaxis

The gene

Basic information

• Locus tag: BSU22910

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:
  • K(D) for c-di-GMP: 1.1 nM PubMed

• Domains:
  • contains a C-terminal PilZ domain PubMed

• Modification:

• Cofactor(s):
  • c-di-GMP PubMed

• Effectors of protein activity:
  • binding of c-di-GMP stimulates the inhibitory interaction with MotA PubMed

• Interactions:
  • DgrA-MotA PubMed

• Localization:

Database entries

• Structure:

• UniProt: P38491

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: dgrA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J Bacteriol: 2013, 195(21);4782-92
[PubMed:23893111] [WorldCat.org] [DOI] (I p)

Yun Chen, Yunrong Chai, Jian-hua Guo, Richard Losick
Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis.
J Bacteriol: 2012, 194(18);5080-90
[PubMed:22821967] [WorldCat.org] [DOI] (I p)