YwcE

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  • Description: holin, required for spore morphogenesis and germination

Gene name ywcE
Synonyms ipa-41r
Essential no
Product holin
Function required for spore morphogenesis and germination
Gene expression levels in SubtiExpress: ywcE
MW, pI 9 kDa, 9.845
Gene length, protein length 261 bp, 87 aa
Immediate neighbours rodA, qoxD
Sequences Protein DNA DNA_with_flanks
Genetic context
YwcE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YwcE expression.png















Categories containing this gene/protein

sporulation/ other, germination, membrane proteins

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

  • Locus tag: BSU38130

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ywcE family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during the log phase (AbrB), expressed only at the onset of stationary phase PubMed
    • strongly induced in response to glucose starvation in M9 medium PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Imke G de Jong, Jan-Willem Veening, Oscar P Kuipers
Single cell analysis of gene expression patterns during carbon starvation in Bacillus subtilis reveals large phenotypic variation.
Environ Microbiol: 2012, 14(12);3110-21
[PubMed:23033921] [WorldCat.org] [DOI] (I p)

Gonçalo Real, Sérgio M Pinto, Ghislain Schyns, Teresa Costa, Adriano O Henriques, Charles P Moran
A gene encoding a holin-like protein involved in spore morphogenesis and spore germination in Bacillus subtilis.
J Bacteriol: 2005, 187(18);6443-53
[PubMed:16159778] [WorldCat.org] [DOI] (P p)

E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933] [WorldCat.org] [DOI] (P p)