BltD

• Description: spermidine/ spermine acetyltransferase
  
  

Gene name	bltD
Synonyms	bmr2D, bmtD
Essential	no
Product	spermidine/ spermine acetyltransferase
Function	spermidine degradation
Gene expression levels in SubtiExpress: bltD
MW, pI	17 kDa, 6.087
Gene length, protein length	456 bp, 152 aa
Immediate neighbours	blt, yrkA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, membrane proteins

This gene is a member of the following regulons

BltR regulon, Mta regulon

The gene

Basic information

• Locus tag: BSU26600

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P39909

• KEGG entry: [3]

• E.C. number: 2.3.1.57

Expression and regulation

• Operon: blt-bltD PubMed

• Expression browser: bltD PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • BltR: transcription activation PubMed
  • Mta: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

D P Woolridge, J D Martinez, D E Stringer, E W Gerner
Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis.
Biochem J: 1999, 340 ( Pt 3)(Pt 3);753-8
[PubMed:10359661] [WorldCat.org] (P p)

N N Baranova, A Danchin, A A Neyfakh
Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters.
Mol Microbiol: 1999, 31(5);1549-59
[PubMed:10200972] [WorldCat.org] [DOI] (P p)

D P Woolridge, N Vazquez-Laslop, P N Markham, M S Chevalier, E W Gerner, A A Neyfakh
Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt.
J Biol Chem: 1997, 272(14);8864-6
[PubMed:9083003] [WorldCat.org] [DOI] (P p)

M Ahmed, L Lyass, P N Markham, S S Taylor, N Vázquez-Laslop, A A Neyfakh
Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.
J Bacteriol: 1995, 177(14);3904-10
[PubMed:7608059] [WorldCat.org] [DOI] (P p)