YcnK

From SubtiWiki
Revision as of 12:33, 16 May 2013 by 134.76.70.252 (talk)
Jump to: navigation, search
  • Description: copper-responsive transcription repressor of the ycnK-ycnJ-ycnI operon

Gene name ycnK
Synonyms
Essential no
Product transcription repressor, DeoR family
Function regulation of copper uptake
Gene expression levels in SubtiExpress: ycnK
MW, pI 21 kDa, 7.371
Gene length, protein length 570 bp, 190 aa
Immediate neighbours ycnJ, ycnL
Sequences Protein DNA DNA_with_flanks
Genetic context
YcnK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YcnK expression.png















Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control

This gene is a member of the following regulons

AbrB regulon, YcnK regulon

The YcnK regulon:

The gene

Basic information

  • Locus tag: BSU03960

Phenotypes of a mutant

  • elevated expression of ycnJ under conditions of copper excess PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: repression of ycnK-ycnJ-ycnI expression in the presence of excess copper PubMed
  • Protein family: DeoR family of transcription factors
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): copper acts as corepressor PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during logrithmic growth (AbrB) PubMed
    • induced by copper limitation (YcnK) PubMed
    • induction of the ycnK-ycnJ-ycnI in a csoR mutant results from intracellular copper depletion due to the constitutive expression of the copZ-copA operon (copper export) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References

Reviews

Original publications