MnaA

• Description: UDP-N-acetylglucosamine 2-epimerase
  
  

Gene name	mnaA
Synonyms	yvyH
Essential	yes PubMed
Product	UDP-N-acetylglucosamine 2-epimerase
Function	biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: mnaA
MW, pI	42 kDa, 5.469
Gene length, protein length	1140 bp, 380 aa
Immediate neighbours	tagU, gtaB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

The gene

Basic information

• Locus tag: BSU35660

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine (according to Swiss-Prot)

• Protein family: UDP-N-acetylglucosamine 2-epimerase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1O6C

• UniProt: P39131

• KEGG entry: [2]

• E.C. number: 5.1.3.14

Expression and regulation

• Operon:

• Expression browser: mnaA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Blazenka Soldo, Vladimir Lazarevic, Harold M Pooley, Dimitri Karamata
Characterization of a Bacillus subtilis thermosensitive teichoic acid-deficient mutant: gene mnaA (yvyH) encodes the UDP-N-acetylglucosamine 2-epimerase.
J Bacteriol: 2002, 184(15);4316-20
[PubMed:12107153] [WorldCat.org] [DOI] (P p)