MdtP

• Description: multidrug-efflux transporter
  
  

Gene name	mdtP
Synonyms	yusP
Essential	no
Product	multidrug-efflux transporter
Function	multidrug resistance
Gene expression levels in SubtiExpress: mdtP
MW, pI	57 kDa, 9.836
Gene length, protein length	1623 bp, 541 aa
Immediate neighbours	mdtR, yusQ
Sequences	Protein DNA DNA_with_flanks
Genetic context

Categories containing this gene/protein

transporters/ other, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

MdtR regulon

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: EmrB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot), membrane associated PubMed

Database entries

• Structure:

• UniProt: O32182

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: mdtR-mdtP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism: repression by MdtR PubMed

• Additional information:

Biological materials

• Mutant: BP70 (spc) available in Fabian Commichau's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ji-Yun Kim, Takashi Inaoka, Kazutaka Hirooka, Hiroshi Matsuoka, Makiko Murata, Reiko Ohki, Yoshikazu Adachi, Yasutaro Fujita, Kozo Ochi
Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.
J Bacteriol: 2009, 191(10);3273-81
[PubMed:19286808] [WorldCat.org] [DOI] (I p)

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)