YtpQ

• Description: unknown
  
  

Gene name	ytpQ
Synonyms
Essential	no
Product	unknown
Function	maybe involved in iron homeostasis
Gene expression levels in SubtiExpress: ytpQ
MW, pI	30 kDa, 5.3
Gene length, protein length	807 bp, 269 aa
Immediate neighbours	ytpR, ytpP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

acquisition of iron, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

Spx regulon

The gene

Basic information

• Locus tag: BSU29830

Phenotypes of a mutant

• derepression of the Fur and PerR regulons PubMed
• elevated oxidative protein damage upon exposure of the cells to methylglyoxal PubMed
• the spx ytpQ doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: UPF0354 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34496

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ytpP-ytpQ-ytpR PubMed

• Expression browser: ytpQ PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • Spx: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Peter Zuber, Shefali Chauhan, Praseeda Pilaka, Michiko M Nakano, Sairam Gurumoorthy, Ann A Lin, Skye M Barendt, Bui Khanh Chi, Haike Antelmann, Ulrike Mäder
Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis.
PLoS One: 2011, 6(9);e25066
[PubMed:21949854] [WorldCat.org] [DOI] (I p)