AdhA

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  • Description: thiol-dependent aldehyde dehydrogenase, repair of damaged thiol-containing proteins

Gene name adhA
Synonyms
Essential no
Product thiol-dependent aldehyde dehydrogenase,
reduction of aldehydes
Function response to toxic formaldehyde
Gene expression levels in SubtiExpress: adhA
MW, pI 37 kDa, 5.367
Gene length, protein length 1047 bp, 349 aa
Immediate neighbours yrzP, yraA
Sequences Protein DNA DNA_with_flanks
Genetic context
AdhA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
AdhA expression.png



























Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

AdhR regulon

The gene

Basic information

  • Locus tag: BSU27010

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde (AdhR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)