BmrR

• Description: general stress protein, transcriptional activator of the bmr-bmrR operon
  
  

Gene name	bmrR
Synonyms
Essential	no
Product	transcriptional activator
Function	regulation of multidrug resistance
Gene expression levels in SubtiExpress: bmrR
MW, pI	32 kDa, 5.187
Gene length, protein length	834 bp, 278 aa
Immediate neighbours	bmr, bkdB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, general stress proteins (controlled by SigB), resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

BmrR regulon, Mta regulon, SigB regulon

The BmrR regulon:

• bmr-bmrR

The gene

Basic information

• Locus tag: BSU24020

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 2BOW (complex with effector), 1R8E (complex with DNA), 1BOW

• UniProt: P39075

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • bmrU-bmr-bmrR PubMed
  • bmr-bmrR PubMed

• Expression browser: bmrR PubMed

• Sigma factor:
  • bmrU: SigB PubMed
  • bmr: SigA PubMed

• Regulation:
  • bmrU: induced by stress (SigB) PubMed
  • bmr: induced by rhodamine 6G and tetraphenylphosphonium (BmrR) PubMed

• Regulatory mechanism:
  • BmrR: transcription activation PubMed
  • Mta: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Richard Brennan, Houston, Texas, USA Homepage