CwlS

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  • Description: D,L-endopeptidase, peptidoglycan hydrolase

Gene name cwlS
Synonyms yojL
Essential no
Product D,L-endopeptidase, peptidoglycan hydrolase
Function cell wall metabolism
Gene expression levels in SubtiExpress: cwlS
MW, pI 44 kDa, 10.438
Gene length, protein length 1242 bp, 414 aa
Immediate neighbours yojM, yojK
Sequences Protein DNA DNA_with_flanks
Genetic context
YojL context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CwlS expression.png
























Categories containing this gene/protein

cell wall degradation/ turnover, membrane proteins

This gene is a member of the following regulons

Abh regulon, AbrB regulon, CcpA regulon, SigD regulon, SigH regulon,

The gene

Basic information

  • Locus tag: BSU19410

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Hydrolysis of gamma-D-glutamyl bonds to the L-terminus (position 7) of meso-diaminopimelic acid (meso-A2pm) in 7-(L-Ala-gamma-D-Glu)-meso-A2pm and 7-(L-Ala-gamma-D-Glu)-7-(D-Ala)-meso-A2pm (according to Swiss-Prot)
  • Protein family: Cu-Zn superoxide dismutase family (according to Swiss-Prot)
  • Paralogous protein(s): the C-terminal D,L-endopeptidase domains of LytE, LytF, CwlS, and CwlO exhibit strong sequence similarity

Extended information on the protein

  • Kinetic information:
  • Domains:
    • C-terminal D,L-endopeptidase domain PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • cell membrane (according to Swiss-Prot)
    • localizes to cell septa and poles PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
    • CcpA: transcription repression
    • Abh and AbrB: synergistic transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed