SqhC

• Description: squalene-hopene cyclase, biosynthesis of sporulenes, protection of the spore against oxidative stress PubMed
  
  

Gene name	sqhC
Synonyms
Essential	no
Product	squalene-hopene cyclase
Function	biosynthesis of sporulenes
Gene expression levels in SubtiExpress: sqhC
MW, pI	71 kDa, 7.633
Gene length, protein length	1896 bp, 632 aa
Immediate neighbours	dhaS, sodF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation proteins, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigE regulon

The gene

Basic information

• Locus tag: BSU19320

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Squalene = hop-22(29)-ene (according to Swiss-Prot) production of sporulenes, polycyclic terpenoid lipids PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: surrounds the forespores PubMed

Database entries

• Structure:

• UniProt: Q796C3

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: sqhC-sodF PubMed

• Expression browser: sqhC PubMed

• Sigma factor: SigE PubMed

• Regulation: expressed during sporulation in the mother cell PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

T Bosak, R M Losick, A Pearson
A polycyclic terpenoid that alleviates oxidative stress.
Proc Natl Acad Sci U S A: 2008, 105(18);6725-9
[PubMed:18436644] [WorldCat.org] [DOI] (I p)