YuaF

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  • Description: NfeD2, role in maintaining membrane integrity during conditions of cellular stress, confers (together with FloT) resistance to cefuroxime

Gene name yuaF
Synonyms
Essential no
Product NfeD family protein NfeD2
Function involved in the control of membrane fluidity
Gene expression levels in SubtiExpress: yuaF
Interactions involving this protein in SubtInteract: YuaF
MW, pI 18 kDa, 4.042
Gene length, protein length 522 bp, 174 aa
Immediate neighbours floT, yuaE
Sequences Protein DNA Advanced_DNA
Genetic context
YuaF context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YuaF expression.png
























Categories containing this gene/protein

membrane dynamics, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

SigW regulon

The gene

Basic information

  • Locus tag: BSU31020

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: NfeD family (with YqeZ)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Felix Dempwolff, Heiko M Möller, Peter L Graumann
Synthetic motility and cell shape defects associated with deletions of flotillin/reggie paralogs in Bacillus subtilis and interplay of these proteins with NfeD proteins.
J Bacteriol: 2012, 194(17);4652-61
[PubMed:22753055] [WorldCat.org] [DOI] (I p)

Christina A Walker, Markus Hinderhofer, David J Witte, Winfried Boos, Heiko M Möller
Solution structure of the soluble domain of the NfeD protein YuaF from Bacillus subtilis.
J Biomol NMR: 2008, 42(1);69-76
[PubMed:18696230] [WorldCat.org] [DOI] (P p)

X Huang, A Gaballa, M Cao, J D Helmann
Identification of target promoters for the Bacillus subtilis extracytoplasmic function sigma factor, sigma W.
Mol Microbiol: 1999, 31(1);361-71
[PubMed:9987136] [WorldCat.org] [DOI] (P p)