RelA

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  • Description: GTP pyrophosphokinase (stringent response)

Gene name relA
Synonyms
Essential no
Product GTP pyrophosphokinase
Function synthesis and degradation of (p)ppGpp,
triggering the stringent response
Gene expression levels in SubtiExpress: relA
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Nucleotides (regulation), Murein recycling
MW, pI 84 kDa, 6.964
Gene length, protein length 2202 bp, 734 aa
Immediate neighbours yrvI, apt
Sequences Protein DNA Advanced_DNA
Genetic context
RelA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RelA expression.png




























Categories containing this gene/protein

metabolism of signalling nucleotides

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU27600

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate (according to Swiss-Prot)
  • Protein family: relA/spoT family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References