Cmk

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  • Description: cytidylate kinase (CMP, dCMP)

Gene name cmk
Synonyms jofC, ypfC
Essential yes PubMed
Product cytidylate kinase (CMP, dCMP)
Function synthesis of CTP and dCTP
Gene expression levels in SubtiExpress: cmk
Metabolic function and regulation of this protein in SubtiPathways:
Pyrimidines, Nucleotides (regulation)
MW, pI 24 kDa, 4.999
Gene length, protein length 672 bp, 224 aa
Immediate neighbours ypfD, ypfB
Sequences Protein DNA Advanced_DNA
Genetic context
Cmk context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Cmk expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22890

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + (d)CMP = ADP + (d)CDP (according to Swiss-Prot)
  • Protein family: Type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1CKE (from Escherichia coli, 38% identity, 54% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

C P Schultz, L Ylisastigui-Pons, L Serina, H Sakamoto, H H Mantsch, J Neuhard, O Bârzu, A M Gilles
Structural and catalytic properties of CMP kinase from Bacillus subtilis: a comparative analysis with the homologous enzyme from Escherichia coli.
Arch Biochem Biophys: 1997, 340(1);144-53
[PubMed:9126287] [WorldCat.org] [DOI] (P p)