FruA

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Gene name fruA
Synonyms
Essential no
Product fructose-specific phosphotransferase system, EIIABC
Function fructose uptake and phosphorylation
Gene expression levels in SubtiExpress: fruA
Interactions involving this protein in SubtInteract: FruA
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 67 kDa, 5.241
Gene length, protein length 1905 bp, 635 aa
Immediate neighbours fruK, sipT
Sequences Protein DNA Advanced_DNA
Genetic context
FruA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FruA expression.png




























Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, membrane proteins, phosphoproteins

This gene is a member of the following regulons

FruR regulon

The gene

Basic information

  • Locus tag: BSU14400

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
  • Protein family: PTS permease, fructose/ mannitol permease (Fru) family PubMed
  • Paralogous protein(s): ManP

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in the presence of fructose (FruR) (according to DBTBS)
  • Regulatory mechanism:
    • FruR: transcription repression (according to DBTBS)
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References