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Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!
Contact: General Microbiology, University of Göttingen, send mail
Upcoming events:
- Deadlines approaching: Abstract submission for the two conferences listed below will end on March 1! Don't miss the date!
- The BACELL meeting 2013 will be held in Newcastle on April 10th and 11th. The meeting will be organized by Leendert Hamoen and Colin Harwood. conference website, contact
- The 7th International Conference on Gram-positive Microorganisms (17th International Conference on Bacilli) organized by Marta Perego, Jim Hoch, and Hendrik Szurmant is going to take place from June 23 - 27, 2013, in Montecatini Terme in lovely Tuscany, Italy, conference website, join the Photo contest and win free Registration!, contact
- Past conferences
New: Subtiwiki is now on Facebook - please give it a +1!
Now online: A description of SubtiWiki, SubtiPathways, and SubtInteract in the 2012 Database issue of Nucleic Acids Research
Paper of the month: February 2013
- For many essential genes of B. subtilis, it is not clear why they are essential in B. subtilis but not in closely related species. Strikingly, this is the case for RNases such as RNases III and Y. Now, Durand et al.. from the lab of Ciaran Condon have identified the reason for the essentiality of RNase III: This enzyme is required to degrade phage encoded toxin mRNA molecules thus protecting the cell from lysis caused by the encoded toxins. Indeed, RNase III is dispensable in a strain lacking the Skin element and the SPß prophage that harbor the corresponding toxin genes.
- Relevant SubtiWiki pages: Ciaran Condon, RNase III, essential genes, yonT, txpA, toxins, antitoxins and immunity against toxins
Durand S, Gilet L, Condon C The essential function of B. subtilis RNase III is to silence foreign toxin genes. PLoS Genet. 2012 8(12): e1003181. PubMed:23300471
- A comment on this paper:
Fabian M Commichau, Jörg Stülke
A mystery unraveled: essentiality of RNase III in Bacillus subtilis is caused by resident prophages.
PLoS Genet: 2012, 8(12);e1003199
[PubMed:23300472]
[WorldCat.org]
[DOI]
(I p)
- See also:
Sylvain Durand, Natalie Jahn, Ciarán Condon, Sabine Brantl
Type I toxin-antitoxin systems in Bacillus subtilis.
RNA Biol: 2012, 9(12);1491-7
[PubMed:23059907]
[WorldCat.org]
[DOI]
(I p)
New procedure for account creation:
- Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
- Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!
News in SubtiWiki:
- January 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
- October 2012: the essential genes have been categorized
- September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
- August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
- April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
- April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
- December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
- December 2010: all genes are linked to regulons, and the pages of the regulons provide an overview on all genes that are members of this specific regulon.
- December 2010: all genes/proteins are linked to categories, and the pages of the categories provide an overview on all genes/proteins that are members of this specific category.
Publications describing SubtiWiki and SubtiPathways:
