YsbA

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  • Description: putative anti-holin

Gene name ysbA
Synonyms lrgA
Essential no
Product putative anti-holin
Function unknown
Gene expression levels in SubtiExpress: ysbA
MW, pI 15 kDa, 9.825
Gene length, protein length 438 bp, 146 aa
Immediate neighbours ysbB, lytT
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YsbA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YsbA expression.png















Categories containing this gene/protein

membrane proteins, proteins of unknown function

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU28910

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: LrgA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • the mRNA is substantially stabilized upon depletion of RNase Y PubMed
    • the expression of the ysbA-ysbB operon is strongly increased in a cshA mutant PubMed

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947

Kelly C Rice, Ethan E Mann, Jennifer L Endres, Elizabeth C Weiss, James E Cassat, Mark S Smeltzer, Kenneth W Bayles
The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus.
Proc Natl Acad Sci U S A: 2007, 104(19);8113-8
[PubMed:17452642] [WorldCat.org] [DOI] (P p)

Kelly C Rice, Jeremy B Nelson, Toni G Patton, Soo-Jin Yang, Kenneth W Bayles
Acetic acid induces expression of the Staphylococcus aureus cidABC and lrgAB murein hydrolase regulator operons.
J Bacteriol: 2005, 187(3);813-21
[PubMed:15659658] [WorldCat.org] [DOI] (P p)