YwcE

• Description: holin, required for spore morphogenesis and germination
  
  

Gene name	ywcE
Synonyms	ipa-41r
Essential	no
Product	holin
Function	required for spore morphogenesis and germination
Gene expression levels in SubtiExpress: ywcE
MW, pI	9 kDa, 9.845
Gene length, protein length	261 bp, 87 aa
Immediate neighbours	rodA, qoxD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation/ other, germination, membrane proteins

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU38130

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ywcE family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P39603

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ywcE PubMed

• Expression browser: ywcE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during the log phase (AbrB), expressed only at the onset of stationary phase PubMed
  • strongly induced in response to glucose starvation in M9 medium PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Charles Moran, Emory University, NC, USA homepage

References

Additional publications: PubMed