SftA

• Description: DNA translocase
  
  

Gene name	sftA
Synonyms	ytpS, cdtA
Essential	no
Product	DNA translocase
Function	resolution of chromosome dimers
Gene expression levels in SubtiExpress: sftA
MW, pI	107 kDa, 5.052
Gene length, protein length	2856 bp, 952 aa
Immediate neighbours	murC, ytpR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation

The gene

Basic information

• Locus tag: BSU29805

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • aids in moving DNA away from the closing septum, binds DNA, DNA-dependent ATPase activity PubMed
  • the two DNA translocases SftA and SpoIIIE synergistically affect chromosome dimer resolution presumably by positioning the dif sites in close proximity, before or after completion of cell division, respectively PubMed

• Protein family:

• Paralogous protein(s): SpoIIIE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • forms a hexamer PubMed

• Localization:
  • Cytoplasm (Homogeneous) PubMed
  • co-localizes with FtsZ at nascent division sites PubMed

Database entries

• Structure:

• UniProt: C0SP86

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: sftA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A984 ( sftA::spec), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Christine Kaimer, Peter L Graumann
Players between the worlds: multifunctional DNA translocases.
Curr Opin Microbiol: 2011, 14(6);719-25
[PubMed:22047950] [WorldCat.org] [DOI] (I p)