LuxS

• Description: S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for swarming motility and biofilm formation
  
  

Gene name	luxS
Synonyms	ytjB
Essential	no
Product	S-ribosylhomocysteine lyase
Function	methionine salvage
Gene expression levels in SubtiExpress: luxS
Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation
MW, pI	17 kDa, 5.168
Gene length, protein length	471 bp, 157 aa
Immediate neighbours	ytkA, ytjA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed 500px

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, motility and chemotaxis, quorum sensing, biofilm formation

The gene

Basic information

• Locus tag: BSU30670

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione (according to Swiss-Prot)

• Protein family: luxS family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: subject to feedback inhibition PubMed

• Interactions:

• Localization:

Database entries

• Structure: 1JQW (complex with homocysteine), 1J98

• UniProt: O34667

• KEGG entry: [3]

• E.C. number: 4.4.1.21

Expression and regulation

• Operon: luxS PubMed

• Expression browser: luxS PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: subject to feedback inhibition PubMed

Biological materials

• Mutant:
  • 1A953 ( luxS::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: