RsbP

• Description: protein serine phosphatase, energy PP2C, dephosphorylates RsbV
  
  

Gene name	rsbP
Synonyms	yvfP
Essential	no
Product	protein serine phosphatase, energy PP2C
Function	control of SigB activity
Gene expression levels in SubtiExpress: rsbP
Interactions involving this protein in SubtInteract: RsbP
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	45 kDa, 4.827
Gene length, protein length	1209 bp, 403 aa
Immediate neighbours	rsbQ, yvfO
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein modification, sigma factors and their control

The gene

Basic information

• Locus tag: BSU34110

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: dephosphorylation of RsbV in response to red light, this results in SigB activation PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: N-terminal PAS domain, central coiled-coil domain, C-terminal PP2C phosphatase domain

• Modification:

• Cofactor(s):

• Effectors of protein activity:
  • activity is stimulated upon interaction of the RsbP oligomer with RsbQ PubMed

• Interactions:
  • RsbP-RsbV PubMed
  • RsbQ-RsbP PubMed

• Localization:

Database entries

• Structure:

• UniProt: O07014

• KEGG entry: [2]

• E.C. number: 3.1.3.3

Expression and regulation

• Operon:

• Expression browser: rsbP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Chet Price, Davis, USA homepage

References

Reviews

Jon Marles-Wright, Richard J Lewis
The stressosome: molecular architecture of a signalling hub.
Biochem Soc Trans: 2010, 38(4);928-33
[PubMed:20658979] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB  
Stochastic pulse regulation in bacterial stress response. 
Science. 2011 334:366-369. 
PubMed:21979936