LiaS

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  • Description: two-component sensor kinase, response to bacitracin

Gene name liaS
Synonyms yvqE
Essential no
Product two-component sensor kinase
Function control of LiaR activity in response to bacitracin
Gene expression levels in SubtiExpress: liaS
Interactions involving this protein in SubtInteract: LiaS
MW, pI 40 kDa, 7.333
Gene length, protein length 1080 bp, 360 aa
Immediate neighbours liaR, liaF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvqE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LiaS expression.png
























Categories containing this gene/protein

protein modification, transcription factors and their control, resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins

This gene is a member of the following regulons

LiaR regulon

The gene

Basic information

  • Locus tag: BSU33090

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of LiaR
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage


Your additional remarks

References

Additional publications: PubMed ,