MdtR

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  • Description: transcription repressor of the multidrug-resistance mdtR-mdtP operon

Gene name mdtR
Synonyms yusO
Essential no
Product transcription repressor (MarR family)
Function regulation of the multidrug-resistance mdtR-mdtP operon
Gene expression levels in SubtiExpress: mdtR
MW, pI 17 kDa, 6.376
Gene length, protein length 465 bp, 155 aa
Immediate neighbours yusN, mdtP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YusO context.gif



Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

MdtR regulon

The MdtR regulon:

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism: repression by MdtR PubMed
  • Additional information:

Biological materials

  • Mutant: GP1115 (spc), available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ji-Yun Kim, Takashi Inaoka, Kazutaka Hirooka, Hiroshi Matsuoka, Makiko Murata, Reiko Ohki, Yoshikazu Adachi, Yasutaro Fujita, Kozo Ochi
Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.
J Bacteriol: 2009, 191(10);3273-81
[PubMed:19286808] [WorldCat.org] [DOI] (I p)