PutP

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  • Description: high affinity proline permease

Gene name putP
Synonyms ycgO
Essential no
Product high affinity proline permease
Function proline uptake
MW, pI 48 kDa, 8.619
Gene length, protein length 1347 bp, 449 aa
Immediate neighbours putC, putR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YcgO context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

transporters/ other, biosynthesis/ acquisition of amino acids, utilization of amino acids membrane proteins

This gene is a member of the following regulons

PutR regulon

The gene

Basic information

  • Locus tag: BSU03220

Phenotypes of a mutant

  • no growth with proline as single source of carbon or nitrogen PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: uptake of proline coupled to the uptake of sodium ions
  • Protein family: sodium solute symporter family (SSS; TC2A.21)
  • Paralogous protein(s): OpuE

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of proline (PutR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Boris R Belitsky
Indirect repression by Bacillus subtilis CodY via displacement of the activator of the proline utilization operon.
J Mol Biol: 2011, 413(2);321-36
[PubMed:21840319] [WorldCat.org] [DOI] (I p)