SodA

• Description: superoxide dismutase, general stress protein, important for survival of ethanol stress and at low temperatures
  
  

Gene name	sodA
Synonyms	yqgD
Essential	no
Product	superoxide dismutase
Function	detoxification of oxygen radicals
MW, pI	22 kDa, 5.203
Gene length, protein length	606 bp, 202 aa
Immediate neighbours	yqgE, yqgC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress, membrane proteins, phosphoproteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU25020

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 superoxide + 2 H⁺ = O₂ + H₂O₂ (according to Swiss-Prot)

• Protein family: iron/manganese superoxide dismutase family (according to Swiss-Prot)

• Paralogous protein(s): SodF

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Thr-34 AND Thr-70 PubMed

• Cofactor(s): manganese

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm PubMed

Database entries

• Structure: 2RCV

• UniProt: P54375

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed
  • constitutive expression PubMed

• Regulatory mechanism:

• Additional information:
  • The mRNA has a long 5' leader region. This may indicate RNA-based regulation PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: