MhqR

• Description: MarR-family transcriptional repressor of azoR2, mhqA, mhqD-mhqE and mhqN-mhqO-mhqP expression
  
  

Gene name	mhqR
Synonyms	ykvE
Essential	no
Product	MarR-family transcriptional repressor
Function	regulation of resistance to quinones and diamide
MW, pI	16 kDa, 6.42
Gene length, protein length	435 bp, 145 aa
Immediate neighbours	kinD, motB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The MhqR regulon

• azoR2, mhqA, mhqD-mhqE and mhqN-mhqO-mhqP

The gene

Basic information

• Locus tag: BSU13670

Phenotypes of a mutant

• resistant to quinones and diamide

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31672

• KEGG entry: [2]

• E.C. number:

Additional information

• Binding site: tATCTcgaAtTCgAGATaaaa PubMed

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

Reviews

Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125] [WorldCat.org] [DOI] (I p)

Original articles

Stefanie Töwe, Montira Leelakriangsak, Kazuo Kobayashi, Nguyen Van Duy, Michael Hecker, Peter Zuber, Haike Antelmann
The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.
Mol Microbiol: 2007, 66(1);40-54
[PubMed:17725564] [WorldCat.org] [DOI] (P p)