SigB

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Gene name sigB
Synonyms rpoF
Essential no
Product RNA polymerase sigma factor SigB
Function general stress response
Interactions involving this protein in SubtInteract: SigB
Metabolic function and regulation of this protein in SubtiPathways:
Stress, Murein recycling
MW, pI 29 kDa, 5.418
Gene length, protein length 792 bp, 264 aa
Immediate neighbours rsbW, rsbX
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SigB context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

transcription, sigma factors and their control, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

CcpA regulon, SigB regulon

The SigB regulon

The gene

Basic information

  • Locus tag: BSU04730

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: SigB subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant: QB5344 (cat), available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews


Control of SigB activity by protein-protein interactions


Identification of the SigB regulon


Other publications

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB  
Stochastic pulse regulation in bacterial stress response. 
Science. 2011 334:366-369. 
PubMed:21979936