Cdd

• Description: cytidine deaminase
  
  

Gene name	cdd
Synonyms
Essential	no
Product	cytidine deaminase
Function	pyrimidine interconversion
Metabolic function and regulation of this protein in SubtiPathways: Nucleoside catabolism, Nucleotides (regulation)
MW, pI	14 kDa, 4.7
Gene length, protein length	408 bp, 136 aa
Immediate neighbours	era, dgkA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

nucleotide metabolism/ other

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU25300

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Cytidine + H₂O = uridine + NH₃ (according to Swiss-Prot)

• Protein family: cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1JTK (complex with inhibitor), 1UWZ (with Arg56Ala substitution)

• UniProt: P19079

• KEGG entry: [3]

• E.C. number: 3.5.4.5

Expression and regulation

• Operon: cdd-era (according to DBTBS)

• Sigma factor: SigA PubMed, SigB PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

N Mejlhede, J F Atkins, J Neuhard
Ribosomal -1 frameshifting during decoding of Bacillus subtilis cdd occurs at the sequence CGA AAG.
J Bacteriol: 1999, 181(9);2930-7
[PubMed:10217788] [WorldCat.org] [DOI] (P p)

B H Song, J Neuhard
Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase.
Mol Gen Genet: 1989, 216(2-3);462-8
[PubMed:2526291] [WorldCat.org] [DOI] (P p)

P Z Wang, R H Doi
Overlapping promoters transcribed by bacillus subtilis sigma 55 and sigma 37 RNA polymerase holoenzymes during growth and stationary phases.
J Biol Chem: 1984, 259(13);8619-25
[PubMed:6330116] [WorldCat.org] (P p)