PadC

• Description: phenolic acid decarboxylase
  
  

Gene name	padC
Synonyms	pad, yveH
Essential	no
Product	phenolic acid decarboxylase
Function	resistance to salicylic acid
MW, pI	18 kDa, 4.871
Gene length, protein length	483 bp, 161 aa
Immediate neighbours	pnbA, yveG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

This gene is a member of the following regulons

PadR regulon

The gene

Basic information

• Locus tag: BSU34400

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: padC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2P8G

• UniProt: O07006

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yveF-yveG-padC PubMed

• Sigma factor:

• Regulation: induced by phenolic acid (PadR) PubMed

• Regulatory mechanism: PadR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Thi Kim Chi Nguyen, Ngoc Phuong Tran, Jean-François Cavin
Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168.
J Bacteriol: 2011, 193(16);4180-91
[PubMed:21685295] [WorldCat.org] [DOI] (I p)

Ngoc Phuong Tran, Jerôme Gury, Véronique Dartois, Thi Kim Chi Nguyen, Hélène Seraut, Lise Barthelmebs, Patrick Gervais, Jean-François Cavin
Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis.
J Bacteriol: 2008, 190(9);3213-24
[PubMed:18326577] [WorldCat.org] [DOI] (I p)

Nguyen Van Duy, Ulrike Mäder, Ngoc Phuong Tran, Jean-François Cavin, Le Thi Tam, Dirk Albrecht, Michael Hecker, Haike Antelmann
The proteome and transcriptome analysis of Bacillus subtilis in response to salicylic acid.
Proteomics: 2007, 7(5);698-710
[PubMed:17295427] [WorldCat.org] [DOI] (P p)

J F Cavin, V Dartois, C Diviès
Gene cloning, transcriptional analysis, purification, and characterization of phenolic acid decarboxylase from Bacillus subtilis.
Appl Environ Microbiol: 1998, 64(4);1466-71
[PubMed:9546183] [WorldCat.org] [DOI] (P p)