PbpE

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Gene name pbpE
Synonyms
Essential no
Product penicillin-binding protein PBP 4* (spore cortex)
Function endopeptidase
MW, pI 51 kDa, 4.835
Gene length, protein length 1353 bp, 451 aa
Immediate neighbours racX, sacB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PbpE context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell wall synthesis, cell wall degradation/ turnover, cell envelope stress proteins (controlled by SigM, W, X, Y)

This gene is a member of the following regulons

AbrB regulon, SigW regulon

The gene

Basic information

  • Locus tag: BSU34440

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: beta-lactamase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: spore cortex

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during logrithmic growth (AbrB) PubMed, probably indirect regulation by AbrB PubMed
    • induced by cell wall stress (SigW) PubMed
  • Regulatory mechanism:
  • Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References