Thi-box
A riboswitch that controls the expression of the tenA-tenI-thiO-thiS-thiG-thiF-thiD and thiU-thiV-thiW-thiX operons as well as of the thiC, thiT, and ylmB genes in response to thiamine. Thiamine pyrophosphate binds the Thi-box resulting in reduced expression.
Important Reviews
Additional publications: PubMed
Juan Miranda-Ríos
The THI-box riboswitch, or how RNA binds thiamin pyrophosphate.
Structure: 2007, 15(3);259-65
[PubMed:17355861]
[WorldCat.org]
[DOI]
(P p)
Narasimhan Sudarsan, Smadar Cohen-Chalamish, Shingo Nakamura, Gail Mitchell Emilsson, Ronald R Breaker
Thiamine pyrophosphate riboswitches are targets for the antimicrobial compound pyrithiamine.
Chem Biol: 2005, 12(12);1325-35
[PubMed:16356850]
[WorldCat.org]
[DOI]
(P p)
Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.
J Biol Chem: 2002, 277(50);48949-59
[PubMed:12376536]
[WorldCat.org]
[DOI]
(P p)
J Miranda-Ríos, M Navarro, M Soberón
A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria.
Proc Natl Acad Sci U S A: 2001, 98(17);9736-41
[PubMed:11470904]
[WorldCat.org]
[DOI]
(P p)
