PsdA

• Description: ABC transporter (ATP-binding protein) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin
  
  

Gene name	psdA
Synonyms	yvcR
Essential	no
Product	ABC transporter (ATP-binding protein)
Function	export of toxic peptides
MW, pI	28 kDa, 6.345
Gene length, protein length	777 bp, 259 aa
Immediate neighbours	psdB, psdS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

The gene

Basic information

• Locus tag: BSU34700

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: PsdA-PsdB PubMed

• Localization: membrane associated (via PsdB) PubMed

Database entries

• Structure:

• UniProt: O06980

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:
  • psdA-psdB PubMed
  • psdR-psdS-psdA-psdB PubMed

• Sigma factor:
  • psdA: SigA PubMed
  • psdR: SigA PubMed

• Regulation:
  • psdA: induced by nisin, gallidermin (PsdR) PubMed

• Regulatory mechanism:
  • PsdR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517] [WorldCat.org] [DOI] (I e)

Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927] [WorldCat.org] [DOI] (I p)

Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)