GreA

• Description: transcription elongation factor
  
  

Gene name	greA
Synonyms
Essential	no
Product	transcription elongation factor
Function	transcription elongation
MW, pI	17 kDa, 4.475
Gene length, protein length	471 bp, 157 aa
Immediate neighbours	pbpI, udk
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription, membrane proteins

The gene

Basic information

• Locus tag: BSU27320

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: greA/greB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P80240

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Padraig Deighan, Ann Hochschild
Conformational toggle triggers a modulator of RNA polymerase activity.
Trends Biochem Sci: 2006, 31(8);424-6
[PubMed:16815708] [WorldCat.org] [DOI] (P p)

Sergei Borukhov, Jookyung Lee, Oleg Laptenko
Bacterial transcription elongation factors: new insights into molecular mechanism of action.
Mol Microbiol: 2005, 55(5);1315-24
[PubMed:15720542] [WorldCat.org] [DOI] (P p)

Bryce E Nickels, Ann Hochschild
Regulation of RNA polymerase through the secondary channel.
Cell: 2004, 118(3);281-4
[PubMed:15294154] [WorldCat.org] [DOI] (P p)

Original Publications

Mohammad Roghanian, Yulia Yuzenkova, Nikolay Zenkin
Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre.
Nucleic Acids Res: 2011, 39(10);4352-9
[PubMed:21266474] [WorldCat.org] [DOI] (I p)

Geoff P Doherty, Donna H Meredith, Peter J Lewis
Subcellular partitioning of transcription factors in Bacillus subtilis.
J Bacteriol: 2006, 188(11);4101-10
[PubMed:16707701] [WorldCat.org] [DOI] (P p)