NatR

• Description: two-component response regulator, regulation of the natA-natB operon
  
  

Gene name	natR
Synonyms	yccH
Essential	no
Product	two-component response regulator
Function	regulation of the natA-natB operon
MW, pI	26 kDa, 6.614
Gene length, protein length	699 bp, 233 aa
Immediate neighbours	natK, natA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

metal ion homeostasis (K, Na, Ca, Mg), transcription factors and their control, phosphoproteins

The NatR regulon:

• natA-natB

The gene

Basic information

• Locus tag: BSU02740

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: OmpR family of two-component response regulators

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by NatK on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions: NatK-NatR

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P70955

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: natR (according to DBTBS)

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Mitsuo Ogura, Kensuke Tsukahara, Kentaro Hayashi, Teruo Tanaka
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Microbiology (Reading): 2007, 153(Pt 3);667-675
[PubMed:17322186] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)