AckA

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  • Description: acetate kinase

Gene name ackA
Synonyms
Essential no
Product acetate kinase
Function overflow metabolism
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 42 kDa, 5.191
Gene length, protein length 1185 bp, 395 aa
Immediate neighbours moaB, ytxK
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AckA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU29470

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Categories containing this gene/protein

ATP synthesis, carbon core metabolism

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + acetate = ADP + acetyl phosphate (according to Swiss-Prot)
  • Protein family: acetokinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 2IIR (from Thermotoga maritima, 54% identity, 73% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expression activated by glucose (2.5 fold) (CcpA) PubMed
    • activated during growth in the presence of branched chain amino acids (CodY) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

Your additional remarks

References