YjbH

• Description: adaptor protein for ClpX-ClpP-catalyzed Spx degradation, confers resistance against nitrosylating agents
  
  

Gene name	yjbH
Synonyms
Essential	no
Product	adaptor protein
Function	stimulation of Spx degradation
MW, pI	31 kDa, 5.206
Gene length, protein length	825 bp, 275 aa
Immediate neighbours	pepF, yjbI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU11550

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

proteolysis

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: adaptor protein for ClpX-ClpP-catalyzed Spx degradation PubMed

• Protein family: UPF0413 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):contains Zn atoms (coordinated by the N-terminal His-rich region) PubMed

• Effectors of protein activity: Zn atom is released upon treatment with strong oxidants PubMed

• Interactions: YjbH-Spx PubMed

• Localization: cytosolic protein

Database entries

• Structure:

• UniProt: O31606

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yjbI-yjbH PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Peter Zuber, Oregon Health and Science University, USA Homepage

Claes von Wachenfeldt, Lund University, Sweden Homepage

References

Reviews

Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260] [WorldCat.org] [DOI] (I p)

Original Publications

Saurabh K Garg, Sushma Kommineni, Luke Henslee, Ying Zhang, Peter Zuber
The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx.
J Bacteriol: 2009, 191(4);1268-77
[PubMed:19074380] [WorldCat.org] [DOI] (I p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilis.
Mol Microbiol: 2007, 66(3);669-84
[PubMed:17908206] [WorldCat.org] [DOI] (P p)

Annika Rogstam, Jonas T Larsson, Peter Kjelgaard, Claes von Wachenfeldt
Mechanisms of adaptation to nitrosative stress in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3063-71
[PubMed:17293416] [WorldCat.org] [DOI] (P p)