ThrC

• Description: threonine synthase
  
  

Gene name	thrC
Synonyms	thrB
Essential	no
Product	threonine synthase
Function	biosynthesis of threonine
Metabolic function and regulation of this protein in SubtiPathways: Lys, Thr
MW, pI	37 kDa, 5.185
Gene length, protein length	1056 bp, 352 aa
Immediate neighbours	thrB, hom
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU32250

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: O-phospho-L-homoserine + H₂O = L-threonine + phosphate (according to Swiss-Prot)

• Protein family: serine/threonine dehydratase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1UIN (from Thermus thermophilus, 51% identity, 69% similarity) PubMed

• UniProt: P04990

• KEGG entry: [2]

• E.C. number: 4.2.3.1

Expression and regulation

• Operon: hom-thrC-thrB PubMed

• Sigma factor:

• Regulation:
  • repressed by casamino acids PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)

C Parsot
Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase.
EMBO J: 1986, 5(11);3013-9
[PubMed:3098560] [WorldCat.org] [DOI] (P p)