ParE

• Description: subunit of DNA topoisomerase IV
  
  

Gene name	parE
Synonyms	grlB
Essential	yes PubMed
Product	subunit of DNA topoisomerase IV
Function	chromosome segregation and compaction
MW, pI	72 kDa, 6.166
Gene length, protein length	1965 bp, 655 aa
Immediate neighbours	yneT, parC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU18090

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

DNA condensation/ segregation, essential genes

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: type II topoisomerase family (according to Swiss-Prot)

• Paralogous protein(s): GyrB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: Nucleoid (Homogeneous) PubMed uniformly distributed throughout the cell PubMed

Database entries

• Structure:

• UniProt: Q59192

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: parE-parC PubMed

• Sigma factor:

• Regulation:
  • induced by DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: