FtsW

• Description: cell-division protein
  
  

Gene name	ftsW
Synonyms	ylaO
Essential	yes PubMed
Product	cell-division protein
Function	cell division
MW, pI	43 kDa, 9.722
Gene length, protein length	1209 bp, 403 aa
Immediate neighbours	ylaN, pycA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU14850

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

cell division, essential genes, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsW/rodA/spoVE family (according to Swiss-Prot) SEDS proteins (shape, elongation, division, and sporulation)

• Paralogous protein(s): RodA, SpoVE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: membrane

Database entries

• Structure:

• UniProt: O07639

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsW-pycA (according to DBTBS)

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • YofA: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Pamela Gamba, Jan-Willem Veening, Nigel J Saunders, Leendert W Hamoen, Richard A Daniel
Two-step assembly dynamics of the Bacillus subtilis divisome.
J Bacteriol: 2009, 191(13);4186-94
[PubMed:19429628] [WorldCat.org] [DOI] (I p)

Gonçalo Real, Allison Fay, Avigdor Eldar, Sérgio M Pinto, Adriano O Henriques, Jonathan Dworkin
Determinants for the subcellular localization and function of a nonessential SEDS protein.
J Bacteriol: 2008, 190(1);363-76
[PubMed:17981970] [WorldCat.org] [DOI] (I p)

Zuolei Lu, Michio Takeuchi, Tsutomu Sato
The LysR-type transcriptional regulator YofA controls cell division through the regulation of expression of ftsW in Bacillus subtilis.
J Bacteriol: 2007, 189(15);5642-51
[PubMed:17526699] [WorldCat.org] [DOI] (P p)