CcdA

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  • Description: membrane-embedded thiol-disulfide oxidoreductase

Gene name ccdA
Synonyms
Essential no
Product thiol-disulfide oxidoreductase
Function cytochrome c synthesis
MW, pI 25 kDa, 9.667
Gene length, protein length 705 bp, 235 aa
Immediate neighbours ynzD, yneI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CcdA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU17930

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Categories containing this gene/protein

respiration, membrane proteins

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: dsbD family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Lýdur S Erlendsson, Lars Hederstedt
Mutations in the thiol-disulfide oxidoreductases BdbC and BdbD can suppress cytochrome c deficiency of CcdA-defective Bacillus subtilis cells.
J Bacteriol: 2002, 184(5);1423-9
[PubMed:11844773] [WorldCat.org] [DOI] (P p)

N E Le Brun, J Bengtsson, L Hederstedt
Genes required for cytochrome c synthesis in Bacillus subtilis.
Mol Microbiol: 2000, 36(3);638-50
[PubMed:10844653] [WorldCat.org] [DOI] (P p)

T Schiött, L Hederstedt
Efficient spore synthesis in Bacillus subtilis depends on the CcdA protein.
J Bacteriol: 2000, 182(10);2845-54
[PubMed:10781554] [WorldCat.org] [DOI] (P p)

T Schiött, M Throne-Holst, L Hederstedt
Bacillus subtilis CcdA-defective mutants are blocked in a late step of cytochrome c biogenesis.
J Bacteriol: 1997, 179(14);4523-9
[PubMed:9226261] [WorldCat.org] [DOI] (P p)

T Schiött, C von Wachenfeldt, L Hederstedt
Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.
J Bacteriol: 1997, 179(6);1962-73
[PubMed:9068642] [WorldCat.org] [DOI] (P p)