CcdA

• Description: membrane-embedded thiol-disulfide oxidoreductase
  
  

Gene name	ccdA
Synonyms
Essential	no
Product	thiol-disulfide oxidoreductase
Function	cytochrome c synthesis
MW, pI	25 kDa, 9.667
Gene length, protein length	705 bp, 235 aa
Immediate neighbours	ynzD, yneI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU17930

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

respiration, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: dsbD family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P45706

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ccdA-yneI-yneJ PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lýdur S Erlendsson, Lars Hederstedt
Mutations in the thiol-disulfide oxidoreductases BdbC and BdbD can suppress cytochrome c deficiency of CcdA-defective Bacillus subtilis cells.
J Bacteriol: 2002, 184(5);1423-9
[PubMed:11844773] [WorldCat.org] [DOI] (P p)

N E Le Brun, J Bengtsson, L Hederstedt
Genes required for cytochrome c synthesis in Bacillus subtilis.
Mol Microbiol: 2000, 36(3);638-50
[PubMed:10844653] [WorldCat.org] [DOI] (P p)

T Schiött, L Hederstedt
Efficient spore synthesis in Bacillus subtilis depends on the CcdA protein.
J Bacteriol: 2000, 182(10);2845-54
[PubMed:10781554] [WorldCat.org] [DOI] (P p)

T Schiött, M Throne-Holst, L Hederstedt
Bacillus subtilis CcdA-defective mutants are blocked in a late step of cytochrome c biogenesis.
J Bacteriol: 1997, 179(14);4523-9
[PubMed:9226261] [WorldCat.org] [DOI] (P p)

T Schiött, C von Wachenfeldt, L Hederstedt
Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.
J Bacteriol: 1997, 179(6);1962-73
[PubMed:9068642] [WorldCat.org] [DOI] (P p)