AhpC

• Description: alkyl hydroperoxide reductase (small subunit)
  
  

Gene name	ahpC
Synonyms	perR
Essential	no
Product	alkyl hydroperoxide reductase (small subunit)
Function	resistance against peroxide stres
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	20 kDa, 4.283
Gene length, protein length	561 bp, 187 aa
Immediate neighbours	gntZ, ahpF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40090

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

resistance against oxidative and electrophile stress, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH (according to Swiss-Prot)

• Protein family: ahpC/TSA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on ser/ thr/ tyr PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1WE0 (from Amphibacillus xylanus, 78% identity, 88% similarity) PubMed

• UniProt: P80239

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ahpC-ahpF PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by H2O2 (PerR) PubMed

• Regulatory mechanism:
  • PerR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: