RnpB

• Description: RNA component of RNase P
  
  

Gene name	rnpB
Synonyms	rnaP
Essential	no
Product	RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)
Function	cleavage of precursor sequences from the 5' ends of pre-tRNAs
Gene length	401 bp
Immediate neighbours	ypsC, ypsB
Gene sequence (+200bp)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

• Structure: 2A64 (from Geobacillus stearothermophilus), 1NBS (specificity domain)

The RNA

• Biological activity: 5' end maturation of precursor tRNAs

• RNA family:

• cofactor: divalent cations (Ca(II) or Mg (II)) for the stabilization of the complex with pre-tRNA PubMed

• interaction: RnpA-RnpB

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/RNA

Roland Hartmann, Marburg University, Germany homepage

References

Reviews

Roland K Hartmann, Markus Gössringer, Bettina Späth, Susan Fischer, Anita Marchfelder
The making of tRNAs and more - RNase P and tRNase Z.
Prog Mol Biol Transl Sci: 2009, 85;319-68
[PubMed:19215776] [WorldCat.org] [DOI] (P p)